The Depraved Town Remake is not a sequel. It is a ground-up rebuild using a newer engine (moving from RPG Maker VX Ace to MZ). The developers promised:
has been redesigned from a flat grid into a vertical nightmare of crumbling Victorian architecture and neon-stained slums. The Story: The Weight of Inheritance You play as depraved+town+remake+patched
If you own the original 2006 game, this remake is now the definitive way to experience the horror of Kuzuryu. If you are new to the series, wait for a sale (likely Halloween), but know that the frustration is gone. The Depraved Town Remake is not a sequel