The Architect of Modern Medicine: Pharmacology in Drug Discovery and Development
Before a drug can ever touch a human, it enters . This stage relies on cell cultures and animal models to answer critical safety questions. Drug Discovery and Development: A Step-By-Step Process pharmacology in drug discovery and development
Targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemia. Pharmacologists demonstrated exquisite selectivity (>1,000-fold over other kinases) and established a PK/PD relationship: trough plasma levels >1 µM correlated with complete cytogenetic response. This pharmacology-driven approach turned a fatal leukemia into a manageable chronic disease. The Architect of Modern Medicine: Pharmacology in Drug