The exact file you need – tw10428.dat (English) – can be extracted from the official CS6 trial. Download the trial via Adobe’s website, run it in a virtual machine, copy the en_US folder, and paste it into your Portable version.
Here’s a clean post you can use on a forum, blog, or social media: adobe photoshop cs6 portable language change to english link
you can convert any Russian/German/Chinese Portable into an English editing machine within five minutes. The exact file you need – tw10428
Find and open application.xml with Notepad++ or any text editor. Find and open application
Adobe Photoshop CS6 includes English as its base language. Localized versions use these .dat files to translate the interface into other languages. By renaming or moving the file, you "break" the translation link, and the program reverts to English without requiring a new download or re-installation.