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She has been a mainstay in long-running series, notably appearing in 25 episodes of Batang Quiapo between 2023 and 2024.

Discovered at the age of 15 in Tondo by the controversial talent manager , Castillo quickly became a staple of the decade's "bold" film genre.

Myrna's media presence has evolved from vintage film roles to digital-era television and behind-the-scenes content: