This is usually a cable issue or a driver conflict. Ensure no other "com-port" software is running in the background.
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Cybersecurity firms have identified cracked industrial software as a top vector for malware. Keyloggers, cryptominers, and ransomware have all been found hidden inside "radio programming software" cracks. Once you run the keygen or patch, you may be giving an attacker full access to your business network. This is usually a cable issue or a driver conflict